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Ausgewählte Publikationen der Abteilung Experimentelle Gynäkologie und Geburtshilfe

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Zenclussen ML, Casalis PA, El-Mousleh T, Rebelo S, Langwisch S, Linzke N, Volk HD, Fest S, Soares MP, Zenclussen AC (2011) Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide. J Pathol, DOI: 10.1002/path. 2946

Leber A, Zenclussen ML, Teles A, Brachwitz N, Casalis P, El-Mousleh T, Jensen F, Woidacki K, Zenclussen AC (2011) Pregnancy: Tolerance and Suppression of Immune Responses. Suppression and Regulation of Immune Responses. Methods and Protocols. Series: Methods in Molecular Biology, Vol. 677: 397-417.
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Jensen F, Woudwyk M, Teles A, Woidacki K, Taran F, Costa S, Fill Malfertheiner S, Zenclussen AC (2010) Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation. PLoS ONE 5 (12): e14409. doi:10.1371/journal.pone.0014409

Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Acruri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ  (2010) The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia. Am J Pathol 177 (5):2472-2482.

Leber A, Teles A, Zenclussen AC (2010) Regulatory Tcells  and their role in pregnancy. Am J Reprod Immunol  63:445-459.

Zenclussen ML, Thuere C, Ahmad N, Wafula PO, Fest S, Teles A, Leber A, Casalis PA, Bechmann I, Priller J, Volk HD, Zenclussen AC  (2010) The persistence of paternal antigens in the maternal body is involved in regulatory T cell expansion and fetal-maternal tolerance in murine pregnancy. Am J Reprod Immunol 63:200-208.

Wafula PO, Teles A, Schumacher A, Pohl K, Yagita H, Volk HD, Zenclussen AC (2009) PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model. Am J Reprod Immunol 62:283-292.

Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Fill Malfertheiner S, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC (2009) Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy.  J Immunol 182:5488-5497.

Zenclussen AC, Kökény G, Thimm O, Sollwedel A, Godo M, Casalis PA, Zenclussen ML, Volk HD, Hamar P. (2008) Mechanisms behind flare of renal lupus during murine pregnancy.  Reprod BioMedicine Online 17 (1):114-126.

Fest S, Brachwitz N, Schumacher A, Zenclussen ML, Khan F, Wafula PO, Casalis PA, Fill S, Costa SD, Mor G, Volk HD, Lode HN, Zenclussen AC (2008) Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation. Am J Reprod Immunol 59 (1):75-83.

Thuere C, Zenclussen ML, Schumacher A, Langwisch S, Schulte-Wrede U, Teles A, Paeschke S, Volk HD, Zenclussen AC (2007) Kinetics of regulatory T cells during murine pregnancy. Am J Reprod Immunol 58 (6):514-523.

Schumacher A, Wafula PO, Zambon Bertoja A, Sollwedel A, Thuere C, Wollenberg I, Yagita H, Volk HD, Zenclussen AC (2007) Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy. Obstetrics & Gynecology 110 (5):1137-1145.

Kökeny G, Godo M, Nagy E, Kardos M, Kotsch K, Casalis P, Bodor C, Rosivall L, Volk HD, Zenclussen AC, Hamar P (2007) Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/lpr mice. Lupus 16 (7):465-477.

Schmid M, Sollwedel A, Thuere C, Zenclussen ML, Wafula PO, Mueller DN, Gratze P, Wociechowsky C, Volk HD, Zenclussen AC (2007) Murine pre-eclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta. Placenta 28 (7): 688-700.

Zenclussen AC, Schumacher A, Zenclussen ML, Wafula P, Volk HD (2007) Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus. Expert Rev Mol Med 9 (10):1-14.

Zenclussen AC (2006) Regulatory T cells and pregnancy. Springer Semin Immunopathol 28 (1):31-39.

Bertoja AZ, Zenclussen ML, Casalis PA, Sollwedel A, Schumacher A, Woiciechowsky C, Volk HD, Zenclussen AC (2006) Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface. Cell Immunol  238 (2):97-102.

Zenclussen AC, Gerlof K, Zenclussen ML, Ritschel S, Zambon Bertoja A, Fest S, Hontsu S, Ueha S, Matsushima K, Leber J, Volk HD (2006) Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur J Immunol 36 (1):82-94.

Zenclussen ML, Bertoja A, Anegon I, Chauveau C, Vogt K, Gerlof K, Sollwedel A, Volk HD, Ritter T, Zenclussen AC (2006) Upregulation of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion. J Reprod Immunol  69 (1):35-52.

Zenclussen AC (2006) A novel mouse model for preeclampsia by transferring activated Th1 cells into normal pregnant mice. Methods Mol Med 122:401-412.

Zambon Bertoja A, Zenclussen ML, Casalis P, Sollwedel A, Schumacher A, Woiciechowsky C, Volk HD, Zenclussen AC (2005) Anti-P+-E selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the fetal-maternal interface. Cell Immunol 238 (2):97-102.

Paeschke S, Chen F, Horn N, Fotopoulou C, Zambon-Bertoja A, Sollwedel A, Zenclussen ML, Casalis PA, Dudenhausen JW, Volk HD, Zenclussen AC (2005) Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood. Am J Reprod Immunol 54:1-6.

Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Zambon Bertoja A, Ritter T, Kotsch K, Leber J, Volk HD (2005) Abnormal T cell reactivity against paternal antigens in spontaneous abortion: Adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 163 (3): 811-822.

Sollwedel A, Zambon Bertoja A, Zenclussen ML, Gerlof K, Lisewski U, Wafula P, Sawitzki B, Woiciechowsky C, Volk HD, Zenclussen AC (2005) Protection from abortion by HO-1 up-regulation is associated with increased levels of bag-1 and neuropilin-1 at the fetal-maternal interface. J Immunol 175:4875-4885.

Zenclussen AC (2005) CD4+CD25+ T regulatory cells in murine pregnancy. J Reprod Immunol 65 (2):101-110.

Zenclussen AC, Zenclussen ML, Ritter T, Volk HD (2005) The use of gene therapy tools in reproductive immunology. Invited Review. Current Gene Therapy 55:459-466.

Zenclussen AC, Fest S, Joachim R, Klapp BF, Arck PC (2004) Introducing a novel mouse model for pre-eclampsia: Adoptive transfer of activated Th1 cells leads to pre-eclampsia like symptoms exclusively in pregnant mice. Eur J Immunol 34 (2):377-387.