Projects

Recently completed projects:

·          Study of the therapeutic potential of CO during implantation in a mouse model of spontaneous abortion (GEMI 018/07). http://www.gemifund.org/international/web/lg/alh/like30lgalhgems.nsf/docbyalias/news_allgrants

·          Characterization of tolerance mechanisms at the fetal-maternal interface - Treg cells and novel tolerance-related molecules" (Fundacao para a Ciencia e Tecnologia SFRH/BD/15893/2005 to Ana Teles)

·          Reprogramming of tolerance in murine models of immunological pregnancy complications through regulatory T cells (DFG Ze 526/4-1) www.dfg.de  

·          Characterization of new tolerance mechanisms in two different in vivo models - Research Grants for exchange (PPP) and Argentina (PROALAR) - DAAD, code D/07/09571 www.daad.de

Ongoing projects:

·          Reprogramming of tolerance in murine models of immunological pregnancy complications through regulatory T cells (DFG Ze 526/4-2) www.dfg.de  

·          Investigation of the therapeutic effect of heme oxygenase and its metabolite carbon monoxide in mouse models of pregnancy complications (DFG Ze 526/5-1) www.dfg.de  

·          Participation of mast cells in regulatory T cells (Treg)-induced tolerance at the fetal-maternal interface: Consequences of mast cells or mast cell-related genes absence in pregnancy outcome (Support by the Fritz-Thyssen-Stiftung, AZ. 10. 08. 2. 179) www.Fritz-Thyssen-Stiftung.de  

·          Mast cells as novel regulators of tolerance at the fetal-maternal interface: their role in pregnancy success as "Treg-helpers" and study of their therapeutic potential in spontaneous abortions (DFG Ze 526/6-1) www.dfg.de and http://www.spp.mastzelle.de

·          Expression regulation of Y-P30 in maternal T cells and their influence on the Neuritogenese thalamic / cortical neurons (funded by the DFG http://www.sfb854.com/index.html,FK854/TP7SFB and http://www.sfb854.de/tp7.html)

·          Immunological Tolerance in Neuroblastoma as a basis for the development of new immunotherapeutic approaches (in collaboration with Dr. Stefan Fest, University Children's Hospital of Magdeburg, AG pediatric immunotherapy, support from the Walter-Schulz-Stiftung) www.walter-schulz-stiftung.de