Research
Many clinically relevant questions and problems are based on processes that are induced and/or maintained by the immune system (e.g. autoimmunity, transplantation immunology, tumor immunology and immunology of infectious diseases).
In order to understand the physiology and pathophysiology of the immune system it is necessary to decode the molecular events and the subcellular structures hat are involved in the induction, maintenance and termination an immune response. The elucidation of these questions is also of importance for developing new strategies allowing diagnosis and therapy of immune-mediated diseases.
Our institute performs research in five key research areas, which are explored by the individual research groups of the institute.
Key technologies such as complex imaging ressources substantially support our research activities.
Additionally, our institute is linked to a variety of research networks, which strengthen our profile as a center for the analysis of signaling pathways and of cell contacts within the the immune system.
News
New Publication on TCR - Adhesion molecular interplay in the journal Blood
Researchers of the SFB recently discovered a new and exciting feature within the interplay between T-cell receptor and adhesion-mediated signaling. Biochemical and imaging technolgies revealed an important function of two independent ADAP/SKAP55-modules for the CCR7-mediated activation of the integrin LFA-1.
mehrSeminare
24.05.2012
LPS recognition and signaling in mast cells: it´s hip to be square
Univ.-Prof. Michael Huber
Institute of Biochemistry and Molecular Biology University Hospital Aachen
30.05.2012
Quantitative proteomics: from regulatory T cells to cellular programming
Dr. Markus Feuerer
DKFZ Heidelberg
Dr. Jeroen Krijgsveld
EMBL Heidelberg