The Systems Biology Laboratory investigates dynamic regulation and control mechanisms of cellular signal transduction networks by a combination of theoretical, experimental and computational methods. We seek to make sense of our biological data with the help of mathematical models, which ideally enable us to make valid predictions for new experiments, thereby generating novel biological insights.
We are an interdisciplinary team of molecular biologists, physicists, mathematicians and engineers, and accordingly we use a broad spectrum of experimental, analytical and computational tools, which are partly developed in the group.

We mainly study eukariotic systems in the following projects:

SysDamSen: Systems biology of DNA-damage induced premature cellular senescence

Sulfosys – Applied Sulfolobus Systems Biology: Exploiting the hot archaeal metabolic potential for Biotechnology

Dynamics of radiation-induced DNA damage repair

Time delay and design patterns of negative feedback control in cellular networks

Signalling crosstalk during response to hyper- and hypo- osmotic shock in yeast

Arsenite stress response in yeast

The role of NFI in growth-dependent regulation of gene expression

This group is partially funded by the GerontoSys initiative from the BMBF

This group is a member of the Max Planck Research School