Startseite
Institute
Molekulare und Klinische Im...
Forschung
Arbeitsgruppen
AG Müller
Publikationen
Publikationen
2022
Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Garbers C, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller AJ, Kahlfuss S.
Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Sci Rep. 2022 Feb 4;12(1):1943. doi: 10.1038/s41598-022-04827-6.
2021
Formaglio P, Alabdullah M, Siokis A, Handschuh J, Sauerland I, Fu Y, Krone A, Gintschel P, Stettin J, Heyde S, Mohr J, Philipsen L, Schröder A, Robert PA, Zhao G, Khailaie S, Dudeck A, Bertrand J, Späth GF, Kahlfuß S, Bousso P, Schraven B, Huehn J, Binder S, Meyer-Hermann M, Müller AJ.
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Immunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Online ahead of print.
Kleinholz CL, Riek-Burchardt M, Seiß EA, Amore J, Gintschel P, Philipsen L, Bousso P, Relja B, Schraven B, Handschuh J, Mohr J, Müller AJ.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection.
Sci Rep. 2021 Jul 23;11(1):15071. doi: 10.1038/s41598-021-94425-9.
Pascual-Reguant A, Köhler R, Mothes R, Bauherr S, Hernández DC, Uecker R, Holzwarth K, Kotsch K, Seidl M, Philipsen L, Müller W, Romagnani C, Niesner R, Hauser AE.
Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.
Nat Commun. 2021 Mar 19;12(1):1737. doi: 10.1038/s41467-021-21994-8.
2020
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR.
Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.
J Am Soc Nephrol. 2020 Aug 28:ASN.2019121289. doi: 10.1681/ASN.2019121289. Online ahead of print. PMID: 32859670
Knop L, Deiser K, Bank U, Witte A, Mohr J, Philipsen L, Fehling HJ, Müller AJ, Kalinke U, Schüler T.
IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Eur J Immunol. 2020 Feb 11. doi: 10.1002/eji.201948368. [Epub ahead of print]
2019
Seiß EA, Krone A, Formaglio P, Goldmann O, Engelmann S, Schraven B, Medina E, Müller AJ.
Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils.
Sci Rep. 2019 Apr 5;9(1):5703. doi: 10.1038/s41598-019-42129-6.
2018
Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Mueller AJ, Schraven B*, Stork O*, Kliche S*.
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells.
Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.
Heyde S, Philipsen L, Formaglio P, Fu Y, Baars I, Höbbel G, Kleinholz C, Seiß EA, Stettin J, Gintschel P, Dudeck A, Bousso P, Schraven B, Müller AJ.
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.
PLoS Pathog. 2018 Oct 22;14(10):e1007374. doi: 10.1371/journal.ppat.1007374 . [Epub ahead of print]
Ewert L, Fischer A, Brandt S, Scurt FG, Philipsen L, Müller AJ, Girndt M, Zenclussen AC, Lindquist JA, Gorny X, Mertens PR.
Cold shock Y-box binding protein-1 acetylation status in monocytes is associated with systemic inflammation and vascular damage.
Atherosclerosis. 2018 Sep 22;278:156-165. doi: 10.1016/j.atherosclerosis.2018.09.020 . [Epub ahead of print]
Holzwarth K, Köhler R, Philipsen L, Tokoyoda K, Ladyhina V, Wählby C, Niesner RA, Hauser AE.
Multiplexed fluorescence microscopy reveals heterogeneity among stromal cells in mouse bone marrow sections.
Cytometry A. 2018 Aug 14. doi: 10.1002/cyto.a.23526 . [Epub ahead of print]
Edelmann B, Gupta N, Schnöder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus RC, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller A, Fischer T.
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.
J Clin Invest. 2018 Jul 19. pii: 90312. doi: 10.1172/JCI90312
Neumann J, Henneberg S, von Kenne S, Nolte N, Müller AJ, Schraven B, Görtler MW, Reymann KG, Gunzer M, Riek-Burchardt M.
Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.
PLoS One. 2018 Mar 15;13(3):e0193970.
2017
Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M.
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.
van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.
TCR signalling network organization at the immunological synapses of murine regulatory T cells.
Eur J Immunol. 2017 Aug 17. doi: 10.1002/eji.201747041. [Epub ahead of print]
TCR signalling network organization at the immunological synapses of murine regulatory T cells.
Eur J Immunol. 2017 Aug 17. doi: 10.1002/eji.201747041. [Epub ahead of print]
Hurrell BP, Beaumann M, Heyde S, Regli IB, Müller AJ, Tacchini-Cottier F.
Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils.
J Leukoc Biol. 2017 Aug 10. pii: jlb.4HI0417-158R. doi: 10.1189/jlb.4HI0417-158R. [Epub ahead of print]
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function.
Blood. 2017 Jul 7. pii: blood-2017-02-767921. doi: 10.1182/blood-2017-02-767921. [Epub ahead of print]
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function.
Blood. 2017 Jul 7. pii: blood-2017-02-767921. doi: 10.1182/blood-2017-02-767921. [Epub ahead of print]
Bernhardt A, Fehr A, Brandt S, Jerchel S, Ballhause TM, Philipsen L, Stolze S, Geffers R, Weng H, Fischer KD, Isermann B, Brunner-Weinzierl MC, Batra A, Siegmund B, Zhu C, Lindquist JA, Mertens PR.
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1.
Kidney Int. 2017 Jun 11. pii: S0085-2538(17)30240-5. doi: 10.1016/j.kint.2017.03.035. [Epub ahead of print]
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1.
Kidney Int. 2017 Jun 11. pii: S0085-2538(17)30240-5. doi: 10.1016/j.kint.2017.03.035. [Epub ahead of print]
Biswas A, French T, Düsedau HP, Mueller N, Riek-Burchardt M, Dudeck A, Bank U, Schüler T, Dunay IR.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.
Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Sci Rep. 2017 Mar 7;7:43985. doi: 10.1038/srep43985.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Sci Rep. 2017 Mar 7;7:43985. doi: 10.1038/srep43985.
Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.
Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes.
Mol Cell Biol. 2017 Jan 4. pii: MCB.00509-16. doi: 10.1128/MCB.00509-16. [Epub ahead of print]
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes.
Mol Cell Biol. 2017 Jan 4. pii: MCB.00509-16. doi: 10.1128/MCB.00509-16. [Epub ahead of print]
2016
Lindquist JA, Hildebrandt J, Philipsen L, Mertens PR.
Immune complexes and complexity: investigating mechanisms of renal disease.
Int Urol Nephrol. 2016 Nov 18. [Epub ahead of print]
Immune complexes and complexity: investigating mechanisms of renal disease.
Int Urol Nephrol. 2016 Nov 18. [Epub ahead of print]
Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.
Saïdi H, Bras M, Formaglio P, Melki MT, Charbit B, Herbeuval JP, Gougeon ML.
HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells.
PLoS Pathog. 2016 Feb 12;12(2):e1005407. doi: 10.1371/journal.ppat.1005407. eCollection 2016.
HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells.
PLoS Pathog. 2016 Feb 12;12(2):e1005407. doi: 10.1371/journal.ppat.1005407. eCollection 2016.
2015
Hurrell BP, Schuster S, Grün E, Coutaz M, Williams RA, Held W, Malissen B, Malissen M, Yousefi S, Simon HU, Müller AJ, Tacchini-Cottier F.
Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.
PLoS Pathog. 2015 May 28;11(5):e1004929. doi: 10.1371/journal.ppat.1004929. eCollection 2015.
Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.
PLoS Pathog. 2015 May 28;11(5):e1004929. doi: 10.1371/journal.ppat.1004929. eCollection 2015.
Neumann J, Riek-Burchardt M, Herz J, Doeppner TR, König R, Hütten H, Etemire E, Männ L, Klingberg A, Fischer T, Görtler MW, Heinze HJ, Reichardt P, Schraven B, Hermann DM, Reymann KG, Gunzer M.
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.Acta Neuropathol.
2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2. Epub 2014 Nov 13.
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.Acta Neuropathol.
2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2. Epub 2014 Nov 13.
2014
Harder T, Guttek K, Philipsen L, Simeoni L, Schraven B, Reinhold D.
Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation.
Cell Commun Signal. 2014 Dec 8;12(1):74. doi: 10.1186/s12964-014-0074-6.
Olekhnovitch R, Ryffel B, Müller AJ, Bousso P.
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
J Clin Invest. 2014 Apr 1;124(4):1711-22. doi: 10.1172/JCI72058. Epub 2014 Mar 10.
Schmerse F, Woidacki K, Riek-Burchardt M, Reichardt P, Roers A, Tadokoro CE, Zenclussen AC.
In vivo visualization of uterine mast cells by 2-photon microscopy.
Reproduction. 2014 Feb 17. [Epub ahead of print]
Jacob D, Ruffie C, Dubois M, Combredet C, Amino R, Formaglio P, Gorgette O, Pehau-Arnaudet G, Guery C, Puijalon O, Barale JC, Ménard R, Tangy F and Sala M.
Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens.
PloS One. 2014; 9(1).
Formaglio P, Tavares J, Ménard R, Amino R.
Loss of host cell plasma membrane integrity following cell traversal by Plasmodium sporozoites in the skin.
Parasitol Int. 2014 ; 63(1) : 237-44.
2013
Müller AJ, Aeschlimann S, Olekhnovitch R, Dacher M, Späth GF, Bousso P.
Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism.
Cell Host Microbe. 2013 Oct 16;14(4):460-7. doi: 10.1016/j.chom.2013.09.008.
Kliese N, Gobrecht P, Pachow D, Andrae N, Wilisch-Neumann A, Kirches E, Riek-Burchardt M, Angenstein F, Reifenberger G, Riemenschneider MJ, Meese E, Panayotova-Dimitrova D, Gutmann DH, Mawrin C.
miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells.
Oncogene. 2013 Sep 26;32(39):4712-20. doi: 10.1038/onc.2012.468. Epub 2012 Oct 29.
Philipsen L, Engels T, Schilling K, Gurbiel S, Fischer KD, Tedford K, Schraven B, Gunzer M, Reichardt P.
Multi-molecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.
Mol Cell Proteomics. 2013 Jun 10. [Epub ahead of print]
Tavares J, Formaglio P, Thiberge S, Mordelet E, Medvinsky A, Ménard R, Amino R.
Role of host cell traversal by the malaria sporozoite during liver infection.
J Exp Med. 2013; 210(5): 905-15.
Tavares J, Formaglio P, Medvinsky A, Ménard R, Amino R.
Imaging sporozoite cell traversal in the liver of mice.
Methods Mol Biol. 2013; 923: 401-10.
Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.
Arndt B, Poltorak M, Kowtharapu BS, Reichardt P, Philipsen L, Lindquist JA, Schraven B, Simeoni L.
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
J Immunol Methods. 2013 Jan 31;387(1-2):276-83. doi: 10.1016/j.jim.2012.11.006. Epub 2012 Nov 22.
2012
Müller AJ, Filipe-Santos O, Eberl G, Aebischer T, Späth GF, Bousso P.
CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.
Immunity. 2012 Jul 27;37(1):147-57. doi: 10.1016/j.immuni.2012.05.015. Epub 2012 Jun 21.
Müller AJ, Kaiser P, Dittmar KE, Weber TC, Haueter S, Endt K, Songhet P, Zellweger C, Kremer M, Fehling HJ, Hardt WD.
Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.
Cell Host Microbe. 2012 Jan 19;11(1):19-32. doi: 10.1016/j.chom.2011.11.013.
2011
Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.
PLoS One. 2011 Feb 23;6(2):e17314.
2010
Berndt U, Philipsen L, Bartsch S, Hu Y, Röcken C, Bertram W, Hämmerle M, Rösch T, Sturm A.
Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma.
Mol Cancer. 2010 Jul 6;9:177.
Henrich-Noack P, Riek-Burchardt M, Reymann KG, Reiser G.
Cellular expression pattern of the protease-activated receptor 4 in the hippocampus in naïve rats and after global ischaemia.
J Neurosci Res. 2010 Mar;88(4):850-7. doi: 10.1002/jnr.22261.
Müller AJ, Hoffmann C, Hardt WD.
Caspase-1 activation via Rho GTPases: A common theme in mucosal infections?
PLoS Pathog. Feb 2010; 6: e1000795.
Riek-Burchardt M, Kolodziej A, Henrich-Noack P, Reymann KG, Höllt V, Stumm R.
Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia.
Neuropharmacology. 2010 Jan;58(1):199-207. doi: 10.1016/j.neuropharm.2009.07.032. Epub 2009 Jul 30.
